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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Skin Irritation – minimal irritation for rabbits (OECD 404).
Eye Irritation – minimal irritation for rabbits (OECD 405).

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

The hydroformylation process, which in general terms is a process involving the preparation of oxygenated organic compounds by the reaction of carbon monoxide and hydrogen (synthesis gas) with carbon compounds containing olefinic unsaturation, and is particularly concerned with the treatment and recycling of by products of the primary oxo-reaction.


The oxo reaction is performed under hydroformylation conditions in the presence of a carbonylation catalyst or catalyst precursor such as dicobaltoctacarbonyl, and results in the formation of a compound e.g. an aldehyde which has one more carbon atom in its molecular structure than the feedstock. Subsequent hydrogenation of the primary product leads to higher alcohols. By virtue of the nature of the feedstock commonly available to industry, and indeed of the catalyst and reaction parameters employed, the hydroformylation reaction inevitably yields a range of products due to the numerous secondary reactions which take place.


The discard alcohol (1,2-Benzenedicarboxylic acid, di-C1-13 alkyl esters, manuf. of, by-products from, distn. lights, CAS#84852-02-8) is a by-product from C6-C8 alcohol formation. Due to compositional similarity, CAS#98072-31-2, will be used as read-across to fill required endpoints.


As assessed in dermal irritation studies, CAS # 98072 -31 -2 is transiently irritating to the skin.  In a study utilizing an occluded patch exposure, the presence of erythema was noted within 4 hours of patch removal and remained present until at least seven days post exposure.  The severity of the erythema induced by CAS # 98072 -31 -2 exposure ranged from very slight to severe during this time frame.  However, upon removal, signs of irritation subside. CAS # 98072 -31 -2 is also transiently irritating to the eye as assessed in rabbits.  Redness was noted in all animals up to 24h post exposure and decreased steadily through 14 days post exposure.

Effect level: empty Endpoint conclusion: Adverse effect observed

Justification for classification or non-classification

No classification for irritation is indicated according to the general classification and labeling requirements for dangerous substances and preparations (Directive 67-548-EEC) or the classification, labeling and packaging (CLP) regulation (EC) No 1272/2008.