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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient experimental details given in incomplete study report.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Principles of method if other than guideline:
Method not specified.
GLP compliance:
no
Remarks:
Study predates adoption of GLP
Test type:
other: No data

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl 2,3-epoxy-3-phenylbutyrate
EC Number:
201-061-8
EC Name:
Ethyl 2,3-epoxy-3-phenylbutyrate
Cas Number:
77-83-8
Molecular formula:
C₁₂H₁₄O₃
IUPAC Name:
ethyl 3-methyl-3-phenyloxirane-2-carboxylate
Details on test material:
- Name of test material (as cited in study report): Aldehyde C16 EOA 76-7
- Substance type: No data
- Physical state: No data
- Analytical purity: No data
- Impurities (identity and concentrations): No data
- Composition of test material, percentage of components: No data
- Isomers composition: No data
- Purity test date: No data
- Lot/batch No.: No data
- Expiration date of the lot/batch: No data
- Stability under test conditions: No data
- Storage condition of test material: No data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: No data
- Fasting period before study: No data
- Housing: No data
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: No data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
VEHICLE
- Concentration in vehicle: No data
- Amount of vehicle (if gavage): No data
- Justification for choice of vehicle: No data
- Lot/batch no. (if required): No data
- Purity: No data

MAXIMUM DOSE VOLUME APPLIED: Up to 5 g/kg body weight

DOSAGE PREPARATION (if unusual): No data

CLASS METHOD (if applicable)
- No data
Doses:
Up to 5 g/kg body weight
No. of animals per sex per dose:
10 animals used, details unclear.
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observation daily on days 1-14
- Necropsy of survivors performed: No data
- Other examinations performed: clinical signs, body weight, organ weights, histopathology, other: No data
Statistics:
No data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
0/10
Clinical signs:
No data
Body weight:
No data
Gross pathology:
No data
Other findings:
- Organ weights: No data
- Histopathology: No data
- Potential target organs: No data

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information
Conclusions:
The acute oral LD₅₀ of the test material ethyl 2,3-epoxy-3-phenylbutyrate was determined as >5000 mg/kg bw.