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Administrative data

Endpoint:
eye irritation, other
Remarks:
in vivo study performed in year 1959
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Sufficient data available.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1959

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
yes
Remarks:
only 50 µl applied
Principles of method if other than guideline:
Method: other: BASF-Test
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
But-2-ene-1,4-diol
EC Number:
203-787-0
EC Name:
But-2-ene-1,4-diol
Cas Number:
110-64-5
Molecular formula:
C4H8O2
IUPAC Name:
2-Butene-1,4-diol
Constituent 2
Chemical structure
Reference substance name:
(Z)-2-butene-1,4-diol
EC Number:
228-085-1
EC Name:
(Z)-2-butene-1,4-diol
Cas Number:
6117-80-2
Molecular formula:
C4H8O2
IUPAC Name:
but-2-ene-1,4-diol
Details on test material:
- Name of test material (as cited in study report): Buten-2-diol-1,4

Test animals / tissue source

Species:
rabbit
Strain:
Vienna White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
other: The adjacent eye served as saline control.
Amount / concentration applied:
TEST MATERIAL
- Amount applied. 0.05 ml
Observation period (in vivo):
8 days
Number of animals or in vitro replicates:
2

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 24 h
Score:
0
Max. score:
4
Reversibility:
other: no effect at all
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 24 h
Score:
0
Max. score:
2
Reversibility:
other: no effect at all
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24 h
Score:
0
Max. score:
4
Reversibility:
other: no effect at all
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 24 h
Score:
0
Max. score:
4
Reversibility:
other: no effect at all

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU

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