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Diss Factsheets

Toxicological information

Endpoint summary

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Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via oral route
Dose descriptor:
NOAEL
100 mg/kg bw/day
Additional information

For the test substance, following values of reproduction toxicity were found:

The NOAEL for REPRODUCTION for MALES is less than 100 mg/kg/day. The value was established on the basis of examination of sperm.

The NOAEL for REPRODUCTION for females was established as 900 mg/kg/day body weight/day.           

The NOAEL for DEVELOPMENT was established as 900 mg/kg/day body weight/day.

The Reproductive screening test result does not confirmed effect on female fertility and offspring development. Due to the unambiguous effect on male fertility is proposed to perform only the Prenatal development toxicity (teratogenicity) study (EU guideline B.31), to investigate the impact of substances on the development of pups and pregnant females.


Short description of key information:
The test substance, Dust, steelmaking, was tested for reproduction toxicity using the OECD Test Guideline No. 421 Reproduction/Developmental Toxicity Screening Test, Adopted by the Council on July 27th 1995. The test was carried out under GLP conditions.

Justification for classification or non-classification

Screening test result did not confirm effect on female fertility and offspring development. There is proposed to carry out the prenatal developmental toxicity (teratogenicity) (EU guideline B.31), to investigate the influence of the test substance on the development of pups and pregnant females.

Additional information