Registration Dossier
Registration Dossier
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EC number: 203-137-6 | CAS number: 103-71-9
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: special investigation
Data source
Reference
- Reference Type:
- publication
- Title:
- Hepatotoxicity of alpha-naphthylisothiocyanate congeners with particulat emphasis on phenylisothiocyanate
- Author:
- Becker BA, Plaa GL
- Year:
- 1 965
- Bibliographic source:
- Toxicol Appl Pharmacol, 7, 804- 811 (1965)
Materials and methods
- Type of study / information:
- hepatotoxicity
- Principles of method if other than guideline:
- the hepatotoxicity of phenyl isocyanate and related compounds was studied
- GLP compliance:
- no
Test material
- Reference substance name:
- Phenyl isocyanate
- EC Number:
- 203-137-6
- EC Name:
- Phenyl isocyanate
- Cas Number:
- 103-71-9
- Molecular formula:
- C7H5NO
- IUPAC Name:
- isocyanatobenzene
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Executive summary:
A single dose of 300 mg/kg bw phenyl isocyanate (or other congeners) in corn oil was administered by stomach tube to 10 male Swiss-Webster mice. Forty-eight hours later, the bilirubin concentrations of the surviving mice were determined. 0/7 animals died, no elevation of plasma bilirubin was detected.
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