Registration Dossier
Registration Dossier
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EC number: 200-293-7 | CAS number: 56-86-0
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The Ames test conducted on glutamic acid showed negative results.
Two Ames tests and two chromosomal aberration tests conducted on monosodium glutamate, an analogue substance showed negative results.
The in vivo micronucleus test showed that monosodium glutamate, an analogue substance, has no clastogenic activity in bone marrow cells of mice (negative).
Monosodium glutamate, an analogue substance, administration at levels up to 5.0% in the diet was not carcinogenic for male and female Fischer 344 rats in the carcinogenicity study.
Based on the results of the in vivo micronucleus test and the carcinogenicity study, the mouse lymphoma study does not appear scientifically necessary.
Short description of key information:
Based on an Ames test (according to OECD 471 and GLP) conducted on glutamic acid and read across from monosodium glutamate (EC 205-538-1):
Monosodium glutamate, an anlogue substance, has been tested in two bacterial reverse mutation tests (equivalent to OECD 471 and GLP), two chromosomal aberration tests (equivalent to OECD 473 and GLP), in vivo micronucleus test (equivalent to OECD 474 and GLP) and carcinogenicity data.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the information in the discussion mentioned above, the substance is not classified for mutagenicity according to DSD and CLP.
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