Registration Dossier
Registration Dossier
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EC number: 808-269-3 | CAS number: 1125812-58-9
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 1-[3-chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoroethan-1-one
- EC Number:
- 808-269-3
- Cas Number:
- 1125812-58-9
- Molecular formula:
- C9H3ClF6O
- IUPAC Name:
- 1-[3-chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoroethan-1-one
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: 7001-7006
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 Mix
- Test concentrations with justification for top dose:
- 7 Concentrations from 0 to 1.563, 3.125, 6.25, 12.5, 25 and 50 µg/mL. The highest concentration is 50 µg/mL because at highest concentration the substance induce bubble formation.
- Vehicle / solvent:
- DMSO
Controls
- Negative solvent / vehicle controls:
- yes
- Positive controls:
- yes
- Positive control substance:
- 4-nitroquinoline-N-oxide
- 2-nitrofluorene
- other: 2-aminoanthracene
Results and discussion
Test results
- Key result
- Species / strain:
- other: 7001-7006
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- valid
- Remarks on result:
- other:
Applicant's summary and conclusion
- Conclusions:
- The MR-008 -3 intermediate is not mutagenic
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