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Long-term toxicity to fish

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Description of key information

One study for long-term toxicity to fish is available, investigating the 100– day chronic toxicity of C8 -18 AAPB conducted according to OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test).

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater fish:
0.135 mg/L

Additional information

Long-term toxicity to fish

In a study conducted according to OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test) and EPA OPPTS 850.1400 (Fish Early-life Stage Toxicity Test), the 100– day chronic toxicity of C8 -18 AAPB to early life stage of rainbow trout (Oncorhynchus mykiss) was investigated under flow through conditions and analytical monitoring of test material concentrations. The mean recovery rates for all concentrations were in the range of 81 – 100 %. Therefore all effect values are based on nominal concentrations. The 37– day NOEC and LOEC values, based on egg hatch, were 0.135 and 0.405 mg a. i./L respectively. The 100– day overall NOEC and LOEC values were 0.135 and 0.405 mg a. i./L, respectively. The effects included were length, dry weight, morphological and behavioral effects, post hatch success and overall survival.

Additional data are available from a prolonged 28-d toxicity study conducted according to OECD Guideline 215 Draft 'Juvenile growth test: 28 d' (1992) (see tableOverview of short-term effects on fish). Rainbow trouts (Oncorhynchus mykiss) were exposed to C8-18 AAPB under flow through conditions. A 28-d NOEC=0.16 mg a. i./L nominal was determined based on growth (body length and mean body wet weight). At higher test concentrations of 0.5 and 1.6 mg a. i./L nominal, the growth rates could not be determined, since all fish died during the test period.

 

Conclusion:

The obtained NOECs of 0.135 and 0.16 mg a. i./L of C8 -18 AAPB were in the same range. The obtained results were considered to be valid for the AAPBs.

The NOEC of 0.135 mg a. i./L obtained from the long-term study including early life-stage was selected for further assessment and derivation of PNEC.