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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: No GLP and no guideline was followed. The number of animals was not provided and few data on methodology was given.
Cross-reference
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1951

Materials and methods

Principles of method if other than guideline:
Penetration of rabbit Skin. DL50 measurement after 14 days.
GLP compliance:
not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Dichloroacetyl chloride

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
14 days
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Statistics:
0.65 (0.53-0.81) ml/kg

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 0.65 mL/kg bw

Any other information on results incl. tables

LD 50 = 0.65 ml/kg (0.53 -0.81) after 14 days

Applicant's summary and conclusion

Conclusions:
The substance DL 50 in penetration of rabbit Skin was DL 50 = 0.65 ml/kg (0.53 -0.81). after 14 days
Executive summary:

The substance DL 50 determined in penetration of rabbit Skin was DL 50 = 0.65 ml/kg (0.53 -0.81) after 14 days.