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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: No GLP and no guideline was followed. The number of animals was low and few data on methodology was provided.
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1951

Materials and methods

Principles of method if other than guideline:
2000ppm vapor inhalation by rats.
GLP compliance:
not specified
Test type:
other: inhalation of known vapour concentration
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Dichloroacetyl chloride
EC Number:
201-199-9
EC Name:
Dichloroacetyl chloride
Cas Number:
79-36-7
Molecular formula:
C2HCl3O
IUPAC Name:
dichloroacetyl chloride
Details on test material:
- Name of test material (as cited in study report): Dichloroacetyl chloride.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
other: no data
Details on inhalation exposure:
2000ppm during 4 hours, observation was during 14 days
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
2000 ppm
No. of animals per sex per dose:
total 6 animals
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
2 000 ppm
Exp. duration:
4 h
Mortality:
Observation of mortality during 14 days

Any other information on results incl. tables

Two of 6 animals were died.

Applicant's summary and conclusion

Conclusions:
LC50 is >2000ppm/4hours (rat)
Executive summary:

LC50 is >2000-ppm/4hours (rat)

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