Registration Dossier
Registration Dossier
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EC number: 201-199-9 | CAS number: 79-36-7
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- No experimental details are given, but just the name of the substance, the concentration of microorganisms, the measuring equipment (Sapromat, manometric respirometry) and the results of a Sapromat measurement. A reference substance was not used to validate test methods. However it it assume that Hoechst AG internal methods are suitable to analyse biodegradation.
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
The target substance DCAC hydrolyses within short time to the source substance and HCl, read across is considered relevant, justified and conservative when using the data from the source substance as they are, i.e., without further assesment factor.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
The target substance DCAC hydrolyses within short time to the source substance and HCl, read across is considered relevant, justified and conservative when using the data from the source substance as they are, i.e., without further assesment factor.
3. ANALOGUE APPROACH JUSTIFICATION
The target substance DCAC hydrolyses within short time to the source substance and HCl, read across is considered relevant, justified and conservative when using the data from the source substance as they are, i.e., without further assesment factor. - Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: microorganisms 100 to 1000 mg/L
- Details on inoculum:
- Not specified
- Duration of test (contact time):
- 15 d
- Initial conc.:
- 340 mg/L
- Based on:
- COD
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- Study acc. to internal guidelines Hoechst AG. The test design (manometric respiration with a Sapromat) indicates OECD F design or similar test methods.
- Parameter:
- % degradation (O2 consumption)
- Value:
- 93
- Sampling time:
- 15 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 45
- Sampling time:
- 10 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 23
- Sampling time:
- 5 d
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Executive summary:
A routine non GLP quality manometric respiration standard test was conducted at Hoechst AG for internal waste water quality control. For that purpose, a Sapromat was used to analyse the biodegradation of DCA for 15 days. A concentration of 340 mg/L COD was exposed to 100 to 1000 g/L microorganisms. The results show that the substance is readily biodegradable, since 93% of DCA were degraded within 15 days (> 70% within 14 days intrapolated) and 23% and 45% were degraded after 5 and 10 days, respectively.
Since the target substance DCAC has a higher molecular weight when compared to the source substance and hydrolyses within short time to the source substance read across is considered relevant, justified and conservative when using the data from the source substance as they are, i.e., without further assesment factor.
Reference
Degradation > 70 % within 14 d (interpolated).
Description of key information
Data waiving: Study technically not feasible. Because of rapid hydrolysis, half-life in water is < 1 sec; measuring biodegradation rates for this substance is not practical.
When getting in contact with water, DCAC hydrolysses very fast to DCA and HCl. Read across data (DCA as source) demonstrate that DCA is readily biodegradable. Hence, it must be concluded that DCAC is also readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
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