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Long-term toxicity to aquatic invertebrates

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Description of key information

No effects up to the limit of water solubility (WS < 0.15 mg/L)

Key value for chemical safety assessment

Additional information

No experimental data evaluating the chronic toxicity of Glycerides, C16-18 mono-, di- and tri- (CAS No. 91052-54-9) to aquatic invertebrates are available. Therefore, toxicity data from a structurally related category member (Glycerides, C14-18 and C16-18 unsatd. mono-, di- and tri-, CAS No. 91052-28-7) are used as read-across in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Both are UVCB substances, formed from the esterification of fatty acids and glycerol, having a high content of C18 fatty acids and to a certain extent C16 fatty acids. Furthermore, their water solubilities are comparable (< 0.05 and < 0.15 mg/L for CAS No. 91052-28-7 and CAS No. 91052-54-9, respectively). Therefore, these two substances are expected to show similar behaviour in the water phase and comparable degrees of toxicity to aquatic organisms. Based on the above information, the use of data from Glycerides, C14-18 and C16-18 unsatd. mono-, di- and tri- as read-across is considered justified.

 

The chronic toxicity of Glycerides,C14-18 and C16-18 unsaturated, mono-, di- and tri- (CAS No. 91052-28-7)to aquatic invertebrates has been evaluated by Salinas (2013). This test was conducted according to OECD 211, under GLP conditions. Daphnia magna was exposed to the substance at a single loading rate of 10 mg/L (limit test) for 21 days within a semi-static water regime. At the end of the exposure period, no effects on survival, reproduction or any other adverse effects were reported. Therefore the NOELR was determined to be ≥ 10 mg/L (nominal, loading rate).

 

Based on the results obtained for the structurally related analogue (in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5), Glycerides, C16-18 mono-, di- and tri- (CAS No. 91052-54-9) is not expected to show long-term toxicity to aquatic invertebrates up to the limit of its water solubility (< 0.15 mg/L).