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Diss Factsheets
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EC number: 222-619-7 | CAS number: 3558-60-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on three hydrolysis studies as-
2 and 3. - GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Analytical monitoring:
- not specified
- Estimation method (if used):
- 2. Structure estimation method
- Remarks:
- 2. The study was performed at pH 7 and 8, respectively.
- Remarks:
- 3. Details not known
- Positive controls:
- not specified
- Negative controls:
- not specified
- Transformation products:
- not specified
- Key result
- pH:
- 7
- DT50:
- 5 yr
- Type:
- second order
- Remarks on result:
- other: 2. Hydrolysis rate constant of test chemical was determined to be 0.04 L/mol-sec
- pH:
- 8
- DT50:
- 200 d
- Type:
- second order
- Remarks on result:
- other: 2. Hydrolysis rate constant of test chemical was determined to be 0.04 L/mol-sec
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- 38 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: 3. Other details not known
- Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 38 days to 5.0 yrs, at pH range 7-8 and a temperature of 25°C.
- Executive summary:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical.The studies are as mentioned below:
The base catalyzed second order hydrolysis rate constant and half-life value of test chemical was determined using a structure estimation method. The second order hydrolysis rate constant was determined to be 0.04 L/mol-sec with a corresponding half-life of 5 years and 200 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
In an another study, the half-life of the test chemical was determined using an estimated pseudo-first order hydrolysis rate constant of 0.00000021/sec.The half-life of test chemical was determined to be 38 days at pH 7 and a temperature of 25°C, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 38 days to 5.0 yrs, at pH range 7-8 and a temperature of 25°C. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.
Reference
Description of key information
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 38 days to 5.0 yrs, at pH range 7-8 and a temperature of 25°C.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 5 yr
Additional information
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical.The studies are as mentioned below:
The base catalyzed second order hydrolysis rate constant and half-life value of test chemical was determined using a structure estimation method. The second order hydrolysis rate constant was determined to be 0.04 L/mol-sec with a corresponding half-life of 5 years and 200 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
In an another study, the half-life of the test chemical was determined using an estimated pseudo-first order hydrolysis rate constant of 0.00000021/sec.The half-life of test chemical was determined to be 38 days at pH 7 and a temperature of 25°C, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 38 days to 5.0 yrs, at pH range 7-8 and a temperature of 25°C. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.
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