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EC number: 203-157-5 | CAS number: 103-90-2
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Chronic toxicity of Paracetamol (acetaminophen) was evaluated using a crustacean (Daphnia magna) in a 21 day study. The No observable effect concentration (NOEC) value of acetaminophen in aquatic crustacean (Dapnia magna) in a 21 day study on various effects were reported as follows:
NOEC (21 days) = 5.72 mg/L (Survival)
NOEC (21 days) = 5.72 mg/L (Reproduction)
NOEC (21 days) = 5.72 mg/L (Population)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 5.72 mg/L
Additional information
Kim,P. et.al (Chemosphere89(1): 10-18) studied Chronic toxicity of Paracetamol (acetaminophen) using freshwater organisms including crustaceans (Daphnia magna and Moina macrocopa). The effects of long-term exposure on D. magna ad M. macrocopa were assessed following OECD guideline 211. In 21 d D. magna exposure, the No observable effect concentration (NOEC) on various effects were reported as NOEC = 5.72 mg/L (Survival, Reproduction and Population). Whereas in 7 d M. macrocopa exposure, the lowest observed effect concentration (LOEC) on various effects were reported as LOEC = 25.75 mg/L (Survival) and 0.95 mg/L (Reproduction).
Based on the long term toxicity test conducted by Ministry of the Environment in Japan/J-CHECK database. The tests are conducted based on OECD-GLP standard and OECD test guidelines. The median effective concentration (EC50) and the No-observable-effect-concentration (NOEC) value of Paracetamol in aquatic invertebrate (Daphnia magna) in a 21days study on the basis of reproduction effect was reported as 3.5 mg/L and 0.46mg/L according to a D. magna reproduction test.
In another study reported by Laira L. et.al ( Drug and chemical toxicoloy 2015 Informa Healthcare USA, Inc. DOI: 10.3109/01480545.2015.1029048), the No-observable-effect-concentration (NOEC) reported as 1.25 mg/L in Daphnia magna in a 21days study on the basis of immobilisation effect.
Our observations suggest however that ecological risks of Paracetamol (acetaminophen) is negligible at the concentrations currently found in the environment.
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