Registration Dossier
Registration Dossier
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EC number: 203-607-0 | CAS number: 108-69-0
Endpoint summary
Administrative data
Description of key information
Oral standard acute method, rats: LD50 710 mg/kg
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Guideline:
- other: no data
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 710 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 470 - <= 1 070
- Clinical signs:
- other:
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- EU GHS
- Conclusions:
- The oral LD50 in rat was described as 710 mg/kg.
- Executive summary:
The test item was assessed in an standard acute toxicity test in rats following national stndard methods. The oral LD50 in rats was determined to be 710 mg/kg.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 710 mg/kg bw
- Quality of whole database:
- data collection of sufficient quality
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Based on the oral median lethal dose of an standard acute toxicity tests in rats, the substance would be classified as Acute toxic Cat. 4 (H302) according to Regulation (EC) No 1272/2008. As Xylidines have an entry in Annex VI of Regulation (EC) No 1272/2008, the harmonised classification is applied: Acute Tox. Cat. 3 (H301)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
