Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Analogous substance CAS 22288 -41 -1 showed no toxicity up to the maximum water solubility, therefore EL50 > ws. A FET (OECD 236) was performed with CAS 22288 -41 -1 and the registered substance to show similarity and to strengthen the read across. A loading of 10 mg/L test material did not result in any significant alterations to Danio rerio embryos for both substances. This concentration is far above the waters solubility of the substance. The results support that the substance is unlikely to be toxic to fish.

Key value for chemical safety assessment

Additional information

A short-term toxicity study according to OECD 203 with 1,1,3,3-tetramethylbutyl peroxypivalate (CAS 22288-41 -1) is available showing no toxicity up to the water solubility limit.

A fish embryo test with the similar substance 1,1,3,3-tetramethylbutyl peroxypivalate (CAS 22288-41 -1) and the registered substance (CAS 22288 -43 -3) was performed as supporting evidence for read across.

A non GLP test was performed according to the fish embryo acute toxicity (FET) test, OECD 236, adopted 26 July 2013. A stock solution in the standard manner was not possible with this material due to the poor solubility of the test substance and likely hood of degradation products being formed. For this reason a WAF approach was used, as described in the RSS, to allow stabilization at the water solubility limit of the parent substance and any other water soluble degradation components that may accumulate during the stirring period. GLP studies had indicated that 6 days stirring was sufficient to measure an increase in the main degradation product and still maintain the parent material at its solubility limit. Test solutions were refreshed daily for a worst case result.

A loading of 10 mg/L test material did not result in any significant effects to Danio rerio embryos. The soluble fraction of the test substances can therefore be concluded as non-toxic to zebra fish embryos at its maximum achievable solubility in the test medium in a semi static 96 hour test with daily refreshment.