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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1986-03-10 to 1986-04-21
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study according to previous OECD TG.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986
Report date:
1986

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method B.1 (Acute Toxicity (Oral))
Deviations:
no
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-nitro-m-xylene
EC Number:
201-947-4
EC Name:
4-nitro-m-xylene
Cas Number:
89-87-2
Molecular formula:
C8H9NO2
IUPAC Name:
2,4-dimethyl-1-nitrobenzene

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: sesame oil
Doses:
1600 mg/kg body weight, 2000 mg/kg body weight, 2500 mg/kg body weight, 3150 mg/kg body weight
No. of animals per sex per dose:
5 male and 5 female rats per dose
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
female
Dose descriptor:
LD50
Effect level:
1 690 mg/kg bw
Based on:
test mat.
95% CL:
1 270 - 2 030
Sex:
male
Dose descriptor:
LD50
Effect level:
2 240 mg/kg bw
Based on:
test mat.
95% CL:
1 840 - 2 730

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Under the conditions of the present study 4-nitro-m-xylene is harmful (Xn, R22) according to 83/467/EEC and Acute Tox. Cat. 4 (H302) according to 1272/2008/EC.