Registration Dossier
Registration Dossier
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EC number: 202-090-9 | CAS number: 91-68-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable and valid study, limited documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 957
- Report date:
- 1957
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method: BASF-Test used before OECD Test Guidelines were in place
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-diethylaminophenol
- EC Number:
- 202-090-9
- EC Name:
- 3-diethylaminophenol
- Cas Number:
- 91-68-9
- Molecular formula:
- C10H15NO
- IUPAC Name:
- 3-(diethylamino)phenol
- Details on test material:
- - Name of test material (as cited in study report): Diäthyl-m-aminophenol
- Physical state: solid
- Analytical purity: 99 %
- Other: soluble in acetic acid, alcohol, lutrol, ethylenechloride, unsoluble in soda solution and vegetable oil
Constituent 1
Test animals
- Species:
- cat
- Strain:
- other: not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- - no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Traganth
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 1-5 %
- Amount of vehicle: 5-10 ml/kg bw - Doses:
- - 50, 200, 500 mg/kg bw
- No. of animals per sex per dose:
- - 50 mg: 2 animals
- 200 or 500 mg: 1 animal each
- sex not specified - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: up to 1 week
- Examinations performed: clinical signs, organ weights/ necropsy, body weight, haematology (methemoglobin)
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- 50 mg/kg bw
- Based on:
- test mat.
- Sex:
- not specified
- Dose descriptor:
- LD100
- Effect level:
- 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- A single oral administration of 200 or 500 mg/ kg bw was lethal within 1 day for both animals tested.
No mortality at 50 mg/ kg bw. - Clinical signs:
- other: 200 or 500 mg/ kg bw: Apathy, vomiting, excessive salivation, strong ataxia and tremor were noticed before excitus . In general symptoms of an anilin-like blood poisoning with formation of methemoglobin were observed. 50 mg: Salivation and vomiting aft
- Gross pathology:
- 200 mg/kg bw: collapsed lung, discolored liver
- Other findings:
- Methemoglobin formation was observed in all dose groups.
Applicant's summary and conclusion
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