Alkenes, C11-12, hydroformylation products, low boiling

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Study period:

1977

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study was well documented and meets generally accepted scientific principles, but was not conducted in compliance with GLP. This study is read across from 1-decanol (CAS 112-30-1).

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Method: other: contract laboratory protocol

GLP compliance:

not specified

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Decan-1-ol

EC Number:

203-956-9

EC Name:

Decan-1-ol

Cas Number:

112-30-1

IUPAC Name:

decan-1-ol

Details on test material:

- Name of test material (as cited in study report): ALFOL 10 Alcohol

- Substance type: alcohol

- Lot/batch No.: 8431J

Test animals

Species:

rat

Strain:

other: COX-CD

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS

- Weight at study initiation: 216 to 253 grams

- Housing: Glass chamber for the duration of exposure to the test substance which after the animals were placed in individual wire-bottomed cages elevated above droppings.

- Diet: Purina laboratory Chow, pelletized (ad libitum)

- Water: ad libitum



IN-LIFE DATES: Not stated.

Administration / exposure

Route of administration:

other: mist

Type of inhalation exposure:

whole body

Vehicle:

other: atmosphere generated as a mist

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION

- Exposure apparatus: DeVilbiss Nebulizer

- Exposure chamber volume: 57 litres

- Method of holding animals in test chamber: shared glass chamber

- Source and rate of air: six litres per minute


TEST ATMOSPHERE

- Brief description of analytical method used: non specified

- Samples taken from breathing zone: not specified



CLASS METHOD (if applicable)

- Rationale for the selection of the starting concentration:

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

1 h

Concentrations:

71 mg/l

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days

- Necropsy of survivors performed: yes

- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: The animals were observed for gross effects at regular intervals on the day of exposure and daily thereafter for fourteen days. All animals were weighed at the beginning and end of the test period.

Statistics:

No statistical analysis performed.

Results and discussion

Preliminary study:

No preliminary study.

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 71 mg/L air

Exp. duration:

1 h

Mortality:

All rats survived the 1 hour exposure and subsequent 14 day  observation period.

Clinical signs:

other: During exposure, all animals displayed hypoactivity and/or ataxia, salivation and gasping. Generalised weakness was also evident when the animals were removed from the chamber at the end of the exposure. At the 24 hour observation period, all animals show

Body weight:

Final bodyweight records of the animals at termination (14 days) showed gains within expected limits, in all animals.

Gross pathology:

Gross necropsy of the animals at fourteen days showed slight to moderate pulmonary (all animals) and adrenal (two animals) congestion; otherwise findings were unremarkable.

Other findings:

The lungs were affected in all rats.

Any other information on results incl. tables

Table 1: Concentrations, exposure conditions and number of evident toxicity per animals treated.

Nominal Conc. (mg/L)	Number with evident toxicity (#/total)
	Males	Females	Combined
71	0/5	0/5	0/10

 

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: other: Federal Hazardous Substances Act

Conclusions:

This study is read across from 1-decanol (CAS 112-30-1). The rat 1 hour LC50 for Alfol 10 (mist) was >71 mg/l. Signs of intoxication during exposure included lethargy,and/or ataxia, salivation and gasping. Gross necropsy revealed congestion of the lungs in all animals.