Registration Dossier
Registration Dossier
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EC number: 214-371-3 | CAS number: 1123-25-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according EU/OECD guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 1-methylcyclohexane-1-carboxylic acid
- EC Number:
- 214-371-3
- EC Name:
- 1-methylcyclohexane-1-carboxylic acid
- Cas Number:
- 1123-25-7
- Molecular formula:
- C8H14O2
- IUPAC Name:
- 1-methylcyclohexane-1-carboxylic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Doses:
- male: 200 and 500 mg/kg body weight (bw)
female: 200, 500 and 2000 mg/kg body weight (bw) - No. of animals per sex per dose:
- 3
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 500 - < 1 000 mg/kg bw
Any other information on results incl. tables
At 200 mg/kg in both genders diarrhea was observed. At 500 mg/kg in both genders decreased motility, uncoordinated gait, labored breathing and temporary tachypnea occurred. Additionally, in the females of this group the skin showed a good blood supply and one male (no. 11) lay in abdominal position. At 2,000 mg/kg females showed dazed condition, poor reflexes, temporary increased motility, uncoordinated gait, abdominal position, laboured breathing and temporary tachypnea, and the skin showed a good blood supply. The signs observed started 25 minutes after administration and lasted up to day 2 of the study.
There were no toxicological effects on body weights or on body weight development in males and females.
In animals that died during the observation period the following changes were detected:
Liver pale discolorations;
Lungs: slightly collapsed;
Spleen: dark-red discolorations;
Kidneys: pale discolorations
Animals killed at the end of the study period showed the following changes:
Thyroid glands: enlarged
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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