Ethylenediamine, salt with phosphoric acid

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Endpoint:

toxicity to microorganisms, other

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

of read across substance

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report is based on two toxicity study of microorganism for the test chemical :
The effect of test material on growth of Pseudomonas fluorescens

GLP compliance:

not specified

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

other: 1)Pseudomonas fluorescens 2) Activated sludge

Test type:

static

Water media type:

freshwater

Total exposure duration:

24 h

Reference substance (positive control):

not specified

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

500 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Duration:

1 h

Dose descriptor:

EC50

Effect conc.:

1 600 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Validity criteria fulfilled:

not specified

Conclusions:

The test chemical is not likely to be toxic to microorganism atleast in the concentartion range of 500-1600 mg/l

Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical .The studies are as mentioned below:

In a study effect of test material was observed on microorganism . The EC0 after 48 h for test organism Pseudomonas fluorescens was observed to be 500 mg/l.

In another study , The effect of test material was tested on activated sludge . The EC50 observed after 1 h for activated sludge was 1600 mg/l.

The test chemical  is not likely to be toxic to microorganism atleast in the concentartion range of 500-1600 mg/l

Description of key information

Toxicity to microorganisms:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical .The studies are as mentioned below:

In a study effect of test material was observed on microorganism . The EC0 after 48 h for test organism Pseudomonas fluorescens was observed to be 500 mg/l.

In another study , The effect of test material was tested on activated sludge . The EC50 observed after 1 h for activated sludge was 1600 mg/l.

The test chemical  is not likely to be toxic to microorganism atleast in the concentartion range of 500-1600 mg/l

Key value for chemical safety assessment

EC50 for microorganisms:

500 mg/L

Additional information

Toxicity to microorganisms:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical .The studies are as mentioned below:

In a study effect of test material was observed on microorganism . The EC0 after 48 h for test organism Pseudomonas fluorescens was observed to be 500 mg/l.

In another study , The effect of test material was tested on activated sludge . The EC50 observed after 1 h for activated sludge was 1600 mg/l.

The test chemical  is not likely to be toxic to microorganism atleast in the concentartion range of 500-1600 mg/l