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EC number: 800-181-3 | CAS number: 371756-75-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Oral:
Reliable data from guideline studies on acute toxicity
after oral application are available for three members of the category
of derivatives of
4,4’-bis(1,3,5-triazinyl-2-yl)amino)stilbene-2,2’-disulfonic acid, each
with one anilino and one alkyl amino moiety: EC 432-690-8, 476-900-6 and
EC 416-640-2. These data reveal avery low acute oral toxicity of this
category: LD50 values for all investigated test items in rats are above
2000 mg/kg bw, the upper limit for classification.Therefore,
it is concluded that the substance defined in section1 is not acute
toxic via the oral route.
Inhalation:
The test material is produced and handled in industry exclusively in aqueous solutions. There are no spraying operations. Thus neither exposure nor risks are expected via the inhalation route.
Dermal:
Reliable data from guideline studies on acute toxicity after dermal
application are available for two members of the category of derivatives
of 4,4’-bis(1,3,5-triazinyl-2-yl)amino)stilbene-2,2’-disulfonic acid,
each with one anilino and one alkyl amino moiety: EC 476-900-6 and EC
416-640-2. These data reveal avery low acute dermal toxicity of this
category: LD50 values for the investigated test items in rats are above
2000 mg/kg bw, the upper limit for classification.Therefore,
it is concluded that the substance defined in section1 is not acute
toxic via the dermal route.
EC 432-690-8:
The acute oral toxicity of the substance when administered by a single
oral gavage to rats was assessed in an OECD 423 study. The substance did
not cause any relevant adverse effects after single oral exposure to
2000 mg/kg bw in rats.
EC 476-900-6:
The acute oral toxicity of the substance when administered by a single
oral gavage to rats was assessed in an OECD 423 study. The test
substance was applied once by oral gavage at a dosage of 2000 mg/kg bw
to two groups of three female rats each followed by a 14 day observation
period. All animals survived until the end of the study. No clinical
signs were observed. Bodyweights of the animals were within the commonly
recorded range for this strain. The LD50 oral, rat (female) was greater
than 2000 mg/kg bw.
The acute dermal toxicity of the test substance when administered by a single dermal application to rats was assessed in an OECD 402 study. Five male and five female rats were treated with the test substance registered at a single dermal dose of 2000 mg/kg bw. Application period was 24 hours followed by a 14 day observation period. No death occurred during the study. No clinical signs were observed. Bodyweights of the animals were within the commonly recorded range for this strain. No macroscopic findings were recorded. The LD50 dermal, rat was greater than 2000 mg/kg.
EC 416-640-2:
The acute oral toxicity of the substance when administered by a single
oral gavage to rats was assessed in an OECD 401 study. The test
substance was applied once by oral gavage at a dosage of 2000 mg/kg bw.
No clinical signs were observed. The LD50 oral, rat was greater than
2000 mg/kg.
The acute dermal toxicity of the test substance when administered by a single dermal application to rats was assessed in an OECD 402 study. Five male and five female rats were treated with the test substance registered at a single dermal dose of 2000 mg/kg bw. Application period was 24 hours followed by a 14 day observation period. No clinical signs were observed. Bodyweights of the animals were within the commonly recorded range for this strain. No macroscopic findings were recorded. The LD50 dermal, rat was greater than 2000 mg/kg.
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available studies are considered reliable and suitable for classification purposes under 67/548/EEC. As a result the category members are not considered to be classified for acute oral, dermal or inhalatory toxicity under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC.
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. As a result the category members are not considered to be classified for acute oral, dermal or inhalatory toxicity under Regulation (EC) No. 1272/2008Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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