Registration Dossier
Registration Dossier
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EC number: 211-941-3 | CAS number: 717-74-8
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- yes
- Type of study:
- Buehler test
Test material
- Reference substance name:
- 1,3,5-triisopropylbenzene
- EC Number:
- 211-941-3
- EC Name:
- 1,3,5-triisopropylbenzene
- Cas Number:
- 717-74-8
- Molecular formula:
- C15H24
- IUPAC Name:
- 1,3,5-tris(propan-2-yl)benzene
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: acetone
- Concentration / amount:
- induction: 25-50%
challenge: 12.5%
Challengeopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- other: acetone
- Concentration / amount:
- induction: 25-50%
challenge: 12.5%
- No. of animals per dose:
- 10
- Details on study design:
- The Buehler test used three six-hour applications at one - week intervals, followed by a challenge two weeks later.
- Positive control substance(s):
- no
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 12.5%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Dose level: 12.5%. No with. + reactions: 0.0. Total no. in groups: 10.0.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The test material, 1,3,5-triisopropylbenzene (TIPB) was determined to be non-sensitizing in guinea pigs
- Executive summary:
The potential for 1,3,5 -triisopropylbenzene (TIPB) to induce dermal sensitization was evaluated using a Buehler test in guinea pigs. A total of 10 guinea pigs were used in this study. For the induction phase, material (50% in acetone) was applied topically to each animal for 6 hours, and this was repeated weekly for a total of 3 applications. Animals were challenged 2 weeks after the last induction treatment using a 12.5% solution of TIPB in acetone. Data indicate that sensitization was not observed in any of the guinea pigs, indicating that TIPB is non-sensitizing.
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