Registration Dossier
Registration Dossier
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EC number: 219-847-4 | CAS number: 2550-26-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Three tests in vitro (Ames, HPRT and MNT) according to data requirements are negative. Further testing on the genetic toxicity of 4 -phenylbutan-2 -one is not required.
Justification for selection of genetic toxicity endpoint
GLP and guideline study performed in mammalian cells to detect the activity of clastogenic and aneugenic chemicals
Short description of key information:
Ames test: negative (±S9 mix)
HPRT test: negative (±S9 mix)
MNT test: negative (± S9 mix)
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the above stated assessments on genotoxicity the test substance 4-phenylbutan-2 -one is not considered to be genotoxic and does not need to be classified according to Council Directive 2001/59/EC (28th ATP of Directive 67/548/EEC) and according to CLP (Regulation (EC) No 1272/2008 of the European Parliament and of the Council) as implementation of UN-GHS in the EU.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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