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EC number: 218-915-0 | CAS number: 2280-49-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity of N-Phenyl-N-[(trichloromethyl)thio]benzenesulphonamide was investigated in different studies. After oral dosing in rat the LD0 was >= 2500 mg/kg and in rabbits the LD0 was >= 1000 mg/kg; in both cases the highest doses tested. After dermal application of 500 mg/kg to 5 rats, no animals showed any intoxication, and consequently the dermal discriminating dose was 500 mg/kg.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study conducted according to accepted scientific criteria
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Principles of method if other than guideline:
- 15 male rats per dose were dosed by gavage. Symptoms and deaths were recorded.
- GLP compliance:
- no
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Route of administration:
- oral: gavage
- Vehicle:
- other: aceton:oil 1:10
- Doses:
- 100, 250, 500, 1000, 2500 g/kg bw
- No. of animals per sex per dose:
- 15 males per group
- Control animals:
- no
- Sex:
- male
- Dose descriptor:
- LD0
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- GHS criteria not met
- Executive summary:
No animal died even at the highest dose 2500 mg/kg.
Reference
Dose level; No of deaths/ no of animals with symptoms/no of deaths.
100; 0/0/15
250; 0/15/15; Animals were free of symptoms on day 2
500;0/15/15; Animals were free of symptoms on day 2
1000; 0/15/15; Animals were free of symptoms on day 4
2500; 0/15/15; Animals were free of symptoms on day 4
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 500 mg/kg bw
- Quality of whole database:
- reliable study in rats
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: highest dose tested: 500 mg/kg
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 5 male rats were dosed with a single dose of 500 mg/kg (25% solution; vehicle oil/acetone 10/1) for 7 days
- GLP compliance:
- no
- Test type:
- other: single dose experiment
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Type of coverage:
- other: open; rats weared a dog-collar
- Vehicle:
- other: oil acetone 10:1
- Duration of exposure:
- 7 days
- Doses:
- 500 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Sex:
- male
- Dose descriptor:
- discriminating dose
- Effect level:
- >= 500 mg/kg bw
- Interpretation of results:
- study cannot be used for classification
- Executive summary:
No symptoms were observed in 5 rabbits at 500 mg/kg, the only dose investigated.
Reference
No symptoms were observed; discriminating does 500 mg/kg
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 500 mg/kg bw
- Quality of whole database:
- reliable study in rats
Additional information
Acute toxicity of N-Phenyl-N-[(trichloromethyl)thio]benzenesulphonamide was investigated in different studies. After oral dosing in rat the LD0 was >= 2500 mg/kg and in rabbits the LD0 was >= 1000 mg/kg; in both cases the highest doses tested. After dermal application of 500 mg/kg to 5 rats, no animals showed any intoxication, and consequently the dermal discriminating dose was 500 mg/kg.
Justification for classification or non-classification
Based on the oral LD0>=2500 mg/kg and the dermal discriminating dose of >= 500 mg/kg no classification is proposed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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