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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

In a bacterial reverse mutation assay with multiple strains of Salmonella typhimurium (similar to OECD TG 471), MMP was negative both with and without metabolic activation. In a mammalian cell gene mutation assay with L5178Y mouse lymphoma cells, exposure to MMP (similar to OECD TG 476) in the presence and absence of metabolic activation did not induce dose-dependent increases in mutation frequency. In an in vitro chromosome aberration test (OECD 473) with and without metabolic activation, MMP did not induce chromosomal aberrations in Chinese hamster V79 cells. MMP induced sister chromatid exchanges (SCE; similar to OECD TG 479) in Chinese hamster ovary cells in the presence and absence of metabolic activation. Although SCE were induced in the presence and absence of metabolic activation by MMP in vitro, based on the consistent lack of genotoxicity in in vitro bacterial and mammalian tests systems MMP is considered to be non genotoxic in vitro and therefore, does not warrant classification.

Short description of key information:
High quality in vitro genetic toxicity studies comparable to OECD guidelines 471, 473, 476, and 479 are available.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Genetic toxicity - Reason for no classification: conclusive but not sufficient for classification