2,2'-isopropylidenebis(p-phenyleneoxy)diethanol

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Study report not available.

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

2004

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 201 (Alga, Growth Inhibition Test)

Deviations:

not specified

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2,2'-isopropylidenebis(p-phenyleneoxy)diethanol

EC Number:

212-985-6

EC Name:

2,2'-isopropylidenebis(p-phenyleneoxy)diethanol

Cas Number:

901-44-0

Molecular formula:

C19H24O4

IUPAC Name:

2,2'-isopropylidenebis(p-phenyleneoxy)diethanol

Constituent 2

Reference substance name:

2-[4-[2-[4-(2-hydroxyethoxy)phenyl]propan-2-yl]phenoxy]ethanol

IUPAC Name:

2-[4-[2-[4-(2-hydroxyethoxy)phenyl]propan-2-yl]phenoxy]ethanol

Constituent 3

Reference substance name:

O(CCO)c1ccc(cc1)C(c1ccc(OCCO)cc1)(C)C

IUPAC Name:

O(CCO)c1ccc(cc1)C(c1ccc(OCCO)cc1)(C)C

Details on test material:

- Molecular formula (if other than submission substance): C19-H24-O4
- Molecular weight (if other than submission substance): 316.4 g/mol
- InChl (if other than submission substance): InChI=1/C19H24O4/c1-19(2,15-3-7-17(8-4-15)22-13-11-20)16-5-9-18(10-6-16)23-14-12-21/h3-10,20-21H,11-14H2,1-2H3

Sampling and analysis

Analytical monitoring:

not specified

Test solutions

Vehicle:

not specified

Test organisms

Test organisms (species):

Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)

Study design

Test type:

not specified

Water media type:

freshwater

Limit test:

no

Total exposure duration:

72 h

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

17 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

growth rate

Effect concentrations 2

Duration:

72 h

Dose descriptor:

NOEC

Effect conc.:

0.95 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

growth rate

Effect concentrations 3

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

3.2 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

biomass

Effect concentrations 4

Duration:

72 h

Dose descriptor:

NOEC

Effect conc.:

0.95 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

biomass

Applicant's summary and conclusion

Validity criteria fulfilled:

not specified

Conclusions:

The effect of the test material on the growth of Selenastrum capricornutum (new name: Pseudokirchnerella subcapitata) has been investigated over a 72-hour period and gave an ErC50 (0-72 h) of 17 mg/L, an EbC50 (0-72 h) of 3.2 mg/L. The No Observed Effect Concentration based on growth rate and biomass was 0.95 mg/L.

Executive summary:

A study was performed to assess the effect of the test material on the growth of the green alga Selenastrum capricornutum (new name: Pseudokirchnerella subcapitata). The method followed is described in the OECD guidelines for Testing of Chemicals No.201.

In terms of growth rate, exposure of Selenastrum capricornutum to the test material gave an ErC50 (0 -72 h) value of 17 mg/L. The No Observed Effect Concentration based on inhibition of growth rate was 0.95 mg/L.

In term of biomass integral (area under growth curve), exposure of Selenastrum capricornutum to the test material gave an EbC50 (0 -72 h) value of 3.2 mg/L. The No Observed Effect Concentration based on inhibition of biomass integral was 0.95 mg/L.