Registration Dossier
Registration Dossier
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EC number: 214-269-9 | CAS number: 1118-84-9
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- Danish QSAR study for CAS No.: 1118-84-9
- Author:
- Danish EPA Model
- Year:
- 2 012
- Bibliographic source:
- QSAR predictions by Danish Environmental Protection Agency (EPA)model powered by OASIS database:-Commercial
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Chromosomal aberrations. Multicase model A61.
- GLP compliance:
- no
- Type of assay:
- in vitro mammalian chromosome aberration test
Test material
- Reference substance name:
- Allyl acetoacetate
- EC Number:
- 214-269-9
- EC Name:
- Allyl acetoacetate
- Cas Number:
- 1118-84-9
- Molecular formula:
- C7H10O3
- IUPAC Name:
- allyl acetoacetate
- Details on test material:
- - Name of test material: allyl acetoacetate
- Molecular formula: C7H10O3
- Molecular weight: 142.15
- Substance type: Organic
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- Chinese hamster Ovary (CHO)
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- not specified
Results and discussion
Test results
- Species / strain:
- Chinese hamster Ovary (CHO)
- Metabolic activation:
- not specified
- Genotoxicity:
- ambiguous
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
ambiguous
Allyl acetoacetate is estimated to be ambiguous according chromosome abberation test in CHO cells. - Executive summary:
Allyl acetoacetate is estimated to be ambiguous according chromosome abberation test in CHO cells.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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