Registration Dossier
Registration Dossier
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EC number: 214-269-9 | CAS number: 1118-84-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Referenceopen allclose all
- Reference Type:
- other: Authoritative data base
- Title:
- HSDB Number: 1083
- Author:
- HSDB Database
- Year:
- 2 011
- Bibliographic source:
- HSDB (Hazardous Substances Data Bank); US national Library of Medicine reviewed by SRC:- European Chemicals Bureau; IUCLID Dataset, Methyl acetoacetate (105-45-3) (2000 CD-ROM edition). Available from, November 3, 2004
- Reference Type:
- other: Authoritative data base
- Title:
- GCID: 15906
- Author:
- ACToR Database
- Year:
- 2 011
- Bibliographic source:
- ACToR (Aggregated Computational Toxicology Resource); European Chemicals Bureau; IUCLID Dataset, Methyl acetoacetate (105-45-3) (2000 CD-ROM edition)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from HSDB, ACToR Database
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Methyl acetoacetate
- EC Number:
- 203-299-8
- EC Name:
- Methyl acetoacetate
- Cas Number:
- 105-45-3
- Molecular formula:
- C5H8O3
- IUPAC Name:
- Methyl acetoacetate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- 1 h
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 26.4 other: mg/L
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Remarks on result:
- other: other details not available
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The 1h acute inhalation toxicity, lethal concentration (LC50) value of methylacetoacetate (vapours) in rat was estimated to be > 26.4 mg/L . This value indicates that methylacetoacetate does not exhibit acute toxicity by the inhalation route.
- Executive summary:
The 1h acute inhalation toxicity, lethal concentration (LC50) value of methylacetoacetate (vapours) in rat was estimated to be > 26.4 mg/L . This value indicates that methylacetoacetate does not exhibit acute toxicity by the inhalation route.
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