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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)

Data source

Referenceopen allclose all

Reference Type:
other: Authoritative data base
Title:
HSDB Number: 1083
Author:
HSDB Database
Year:
2011
Bibliographic source:
HSDB (Hazardous Substances Data Bank); US national Library of Medicine reviewed by SRC:- European Chemicals Bureau; IUCLID Dataset, Methyl acetoacetate (105-45-3) (2000 CD-ROM edition). Available from, November 3, 2004
Reference Type:
other: Authoritative data base
Title:
GCID: 15906
Author:
ACToR Database
Year:
2011
Bibliographic source:
ACToR (Aggregated Computational Toxicology Resource); European Chemicals Bureau; IUCLID Dataset, Methyl acetoacetate (105-45-3) (2000 CD-ROM edition)

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Data is from HSDB, ACToR Database
GLP compliance:
not specified
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Duration of exposure:
1 h
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 26.4 other: mg/L
Based on:
test mat.
Exp. duration:
1 h
Remarks on result:
other: other details not available

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The 1h acute inhalation toxicity, lethal concentration (LC50) value of methylacetoacetate (vapours) in rat was estimated to be > 26.4 mg/L . This value indicates that methylacetoacetate does not exhibit acute toxicity by the inhalation route.
Executive summary:

The 1h acute inhalation toxicity, lethal concentration (LC50) value of methylacetoacetate (vapours) in rat was estimated to be > 26.4 mg/L . This value indicates that methylacetoacetate does not exhibit acute toxicity by the inhalation route.