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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)

Data source

Referenceopen allclose all

Reference Type:
other: Authoritative data base
Title:
HSDB Number: 1083
Author:
HSDB Database
Year:
2011
Bibliographic source:
HSDB (Hazardous Substances Data Bank); US national Library of Medicine reviewed by SRC:- European Chemicals Bureau; IUCLID Dataset, Methyl acetoacetate (105-45-3) (2000 CD-ROM edition). Available from, November 3, 2004
Reference Type:
other: Authoritative data base
Title:
GCID: 15906
Author:
ACToR Database
Year:
2011
Bibliographic source:
ACToR (Aggregated Computational Toxicology Resource); European Chemicals Bureau; IUCLID Dataset, Methyl acetoacetate (105-45-3) (2000 CD-ROM edition)

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from HSDB, ACToR Database
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl acetoacetate
EC Number:
203-299-8
EC Name:
Methyl acetoacetate
Cas Number:
105-45-3
Molecular formula:
C5H8O3
IUPAC Name:
Methyl acetoacetate

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Duration of exposure:
1 h
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 26.4 other: mg/L
Based on:
test mat.
Exp. duration:
1 h
Remarks on result:
other: other details not available

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The 1h acute inhalation toxicity, lethal concentration (LC50) value of methylacetoacetate (vapours) in rat was estimated to be > 26.4 mg/L . This value indicates that methylacetoacetate does not exhibit acute toxicity by the inhalation route.
Executive summary:

The 1h acute inhalation toxicity, lethal concentration (LC50) value of methylacetoacetate (vapours) in rat was estimated to be > 26.4 mg/L . This value indicates that methylacetoacetate does not exhibit acute toxicity by the inhalation route.