Registration Dossier

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
DOSE No: M152
Author:
RSC Publishing
Year:
2011
Bibliographic source:
Dictionary of Substances and their effects (DOSE):- Romashov, P. G. et al Gig. Sanit. 1991, (3), 20-22 (Russ.) (Chem. Abstr. 115, 200734x).; Smyth, H. F. et al J. Ind. Hyg. Toxicol. 1948, 30, 63.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Data is from DOSE.
GLP compliance:
not specified
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
other animals tested: rat, rabbit

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 250 - 3 500 other: mg/kg
Based on:
test mat.
Remarks on result:
other: other details not available

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 value for oral exposure of methyl acetoacetate is found to be 1250-3500 mg/kg in the various species used in the study.
Executive summary:

The LD50 value for oral exposure of methyl acetoacetate is found to be 1250-3500 mg/kg in the various species used in the study.