Registration Dossier

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
other: Weight of evidence
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Weight of evidence
Title:
Toxicokinetics
Author:
Sustainability Support Services (Europe) AB
Year:
2012
Bibliographic source:
Based on the weight of evidence of various phys chem and bioaccumulative parameters in the dossier

Materials and methods

Objective of study:
toxicokinetics
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Based on the weight of evidence of various phys chem and bioaccumulative parameters in the dossier
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
other: unspecified
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: estimation
Vehicle:
unchanged (no vehicle)

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:
Absorption of allyl acetoacetate via the inhalation route is expected since its vapour pressure is 85-59 Pa. Assuming that the absoprtion via the other route of exposure (oral or intravenous) is significant, but since the bio-concentration factor (BCF) of allyl acetoacetate is very low (3.2) even if the chemical is absorbed within the living system it shall not bio-accumulate and thereby no bio-concentration shall occur within the living system.




Details on distribution in tissues:
The water solubility of allyl acetoacetate is poor compred to its solubility in organic solvents. Thus it is expected that the chemical shall not be distribute via blood to the other rgans of the body but it could distribute in those areas of the body where the lipid content is high. However, given the fact that it will not bio-accumulate or bio-concentrate will ensure its elimination from the human body.


Details on excretion:
As chemicals are absorbed at different entry portals, they can be excreted via various routes and mechanisms. The relative importance of the excretion processes depends on the physical and chemical properties of the compound and its various metabolites. There are no available reports of allyl acetoacetate metabolites being formed upon absorption. Also given the fact that the chemical has very low bio-concentration factor, it is assumed that allyl acetoacetate shall be excreted mostly unchanged from the body via the faeces (given that the molecular weight is less than 300 and poor water solubility) or through urine .

Metabolite characterisation studies

Metabolites identified:
no

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): other: No bio-accumulation potential deduced on the basis of physico-chemical properties and molecular weight
Based upon the physico-chemical properties and bio-concentration factor of allyl acetoacetate, it has been deduced that the chemical has potentially low bio-accumulative property and hence shall be rapidly eliminated from the body system through the bile/feaces or urine.
Executive summary:

Based upon the physico-chemical properties and bio-concentration factor of allyl acetoacetate, it has been deduced that the chemical has potentially low bio-accumulative property and hence shall be rapidly eliminated from the body system through the bile/feaces or urine.