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EC number: 939-485-7
CAS number: 218141-16-3
The study was performed with
similarities to OECD Guideline 423 (Acute Oral Toxicity - Acute Toxic
Class Method) and according to GLP standards (audited in-house).
The test material, Etheramine C8-10
was evaluated for its acute oral toxicity potential in rats when
administered as gavage doses at levels of 25, 200 and 2000 mg/kg to two
males and two females. Dosing started with the lowest dose. As no deaths
occurred at this level within 24 hours, the next dose was given to
another group, and so on. At the 2000 mg/kg level all four animals died.
Clinical signs of toxicity included pilo-erection, hunched posture and
increased salivation accompanied by lethargy, abnormal gait, decreased
respiratory rate and pallor of the extremities. Gross pathologic
examination on the animals that died showed congestion or haemorrhage of
the lungs, pallor of the liver and kidneys and haemorrhage of the
stomach blood vessels. Gross pathologic examination at termination
revealed nothing remarkable.
Conclusion: The acute oral LD50 of
Etheramine 810 for rats is between 200 and 2000 mg/kg of body weight.
Confidence limits could not be calculated.
The etheramine is (very) corrosive.
The test substance was administrated undiluted at 200 and 2000 mg/kg
with 0.24 ml/kg resp. 2.4 ml/kg. Autopsy of the animals that died from
2.4 ml/kg, showed haemorrhage of the stomach. At 0.24 ml/kg the
undiluted substance was likely to be just as corrosive locally, however,
the volume dose was not sufficient to cause the death of the animals,
and they fully recovered. It is uncertain what would happen at 300 mg/kg
when 0.36 ml/kg would be dosed, but it is expected that most of the
animals would survive this.
Etheramine C8-10 is classified for GHS as Toxicity Category 4 with LD50
cut-off of 500 mg/kgbw.
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