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Short-term toxicity to aquatic invertebrates

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Description of key information

48h-EC50 > 0.08 mg/L (measured)
48h-EC50 > 0.006 mg/L (limit water solubility)
No toxic effects are to be expected up to the limit of water solubility.

Key value for chemical safety assessment

Additional information

The acute toxicity of SP-334 (2-(2-hexyl-decyloxy)-benzamide) to aquatic invertebrates was investigated in a study conducted by Bogers (1998), according to OECD Guideline 202 under GLP conditions. Due to the poor water solubility of the substance (≤ 0.006 mg/L) a homogeneous solution could not be achieved by physical means (magnetic stirring and ultrasonic treatment) after addition of the test substance. Therefore, for the final test 10, 18, 32, 56 and 100% of a filtrate of test solution (5 µm) was prepared at 10 mg/L nominal using acetone as solvent (1 mL/L). Analytical measurements of the test concentrations were performed with HPLC. The results from the range-finding study showed 40% immobility at the highest concentration tested (10 mg/L). However, undissolved material could be clearly observed at the bottom and surface of the test vessels and therefore, is assumed to have caused this effect.

In the final test, daphnids were exposed to the test substance for 48 hours under static conditions and immobility was recorded at 24 and 48 hours. No immobility could be observed up to a concentration of 10 mg/L nominal (0.08 mg/L measured concentration).

In conclusion, SP-334 is not acutely toxic to aquatic invertebrates within the range of its water solubility (≤ 0.006 mg/L).