Registration Dossier
Registration Dossier
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EC number: 200-186-5 | CAS number: 53-86-1
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Experimental results did not indicate an irritant potential of indomethacin. Studies of eye irritation (scoring according to Draize) revealed at most a minimal potential for eye irritation with complete recovery within 24 hours. In house data on skin irritation are not available. However, skin sensitization tests with a challenge concentration of 10% indomethacin in petrolatum gave no indiacation for a skin irritating potential in the guinea pig (Maurer 1985, Curr. Probl. Derm. Vol. 14, pp. 114 -151).
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Classification is not required according to 67/548/EEC and Regulation (EC) 1272/2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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