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Diss Factsheets
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EC number: 939-526-9 | CAS number: 90506-73-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May to August 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted according to OECD under GLP conditions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 bis (Acute Oral Toxicity - Fixed Dose Procedure)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Octadecyl dihydrogen phosphate
- EC Number:
- 220-983-1
- EC Name:
- Octadecyl dihydrogen phosphate
- Cas Number:
- 2958-09-0
- Molecular formula:
- C18H39O4P
- IUPAC Name:
- octadecyl dihydrogen phosphate
- Reference substance name:
- Hexadecyl dihydrogen phosphate
- EC Number:
- 222-581-1
- EC Name:
- Hexadecyl dihydrogen phosphate
- Cas Number:
- 3539-43-3
- Molecular formula:
- C16H35O4P
- IUPAC Name:
- hexadecyl dihydrogen phosphate
- Reference substance name:
- Dioctadecyl hydrogen phosphate
- EC Number:
- 221-237-8
- EC Name:
- Dioctadecyl hydrogen phosphate
- Cas Number:
- 3037-89-6
- Molecular formula:
- C36H75O4P
- IUPAC Name:
- dioctadecyl hydrogen phosphate
- Reference substance name:
- Dihexadecyl hydrogen phosphate
- EC Number:
- 218-594-7
- EC Name:
- Dihexadecyl hydrogen phosphate
- Cas Number:
- 2197-63-9
- Molecular formula:
- C32H67O4P
- IUPAC Name:
- dihexadecyl hydrogen phosphate
- Reference substance name:
- hexadecyl octadecyl hydrogen phosphate
- Cas Number:
- 93803-11-3
- Molecular formula:
- C34H71O4P
- IUPAC Name:
- hexadecyl octadecyl hydrogen phosphate
- Reference substance name:
- Unidentified impurities, likely the C16 and C18, and mixed C16/C18 trialkyl phosphates based 31P NMR chemical shift.
- Molecular formula:
- N/A
- IUPAC Name:
- Unidentified impurities, likely the C16 and C18, and mixed C16/C18 trialkyl phosphates based 31P NMR chemical shift.
- Test material form:
- solid
- Details on test material:
- CAS Number 39471-52-8
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
impurity 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Animals were nulliparous and non-pregnant
Acclimatization; at least 5 days
Animals age: 8 to 12 weeks
Body weight: No variation greater than ±20% body weight
Animal housing: Suspended solid-floor polypropylene cages, groups of 4 animals in each cage.
Free access to water and food.
Temperature: 19 to 25ºC
Humidity: 30 to 70%
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Details on oral exposure:
- Single dose by oral gavage, volume administered to each animal according to the fasted body weight.
- Doses:
- 1 dose at 2,000 mg/kg
- No. of animals per sex per dose:
- 1animal at 300 mg/kg for pre-liminary test
5 animals per dose level - Control animals:
- no
- Details on study design:
- A total of 5 animals were treated at a dose level of 2,000 mg/kg in the study.
All animals were dosed once by gavage using a metal cannula attached to a graduated syringe. The volume administered to each animal was calculated according to the fasted body weight at the time of dosing. Treatment of animals was sequential. Sufficient time was allowed between each dose level to confirm the survival of the previously dosed animals.
Clinical observations were made at 30 minutes, 1, 2 and 4 hours after dosing and then daily for 14 days. Morbidity and mortality checks were made twice daily. Individual body weights were recorded on Day 0, Day 7 and Day 14.
At the end of the observation period the animals were killed by cervical dislocation. All animals were subject to gross pathology and this consisted of an external examination and opening of the abdominal and thoracic cavities.
The appearance of any macroscopic abnormalities was recorded. No tissues were retained.
Results and discussion
- Preliminary study:
- 300 mg/kg on pre-liminary test
Mortality: There was no mortality
Clinical signs: No signs of systematic toxicity were noted in the observation period.
Body weight: The animal showed expected gains in body weight over the observation period.
Gross pathology: No abnormalities were noted at necropsy.
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no deaths
- Clinical signs:
- other: No signs of systematic toxicity were noted in the observation period.
- Gross pathology:
- No abnormalities were noted at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Conclusions:
- The acute oral median lethal dose (LD50) of the test material in the female Wistar strain rat is greater than 2,000 mg/kg bw .
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