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Acute tests evaluating the toxicity of 2-(1-methylethoxy)ethyl acetate (CAS 19234-20-9) to aquatic organisms from three different trophic levels are available. The available studies with the aquatic invertebrate Daphnia magna and the freshwater algae Pseudokirchneriella subcapitata did not result in any toxicity based on mobility and growth rate, respectively, with EC50 values > 100 mg/L (nominal). Fish turned out to be the most sensitive species with a LC50 (96 h) of 42 mg/L (nominal). Long-term toxicity testing was not deemed necessary. The environmental exposure assessment for 2-(1-methylethoxy)ethyl acetate according to Annex XI, Section 3 of Regulation (EC) No 1907/2006 indicates no risk for the aquatic compartment (all RCR < 1; please refer to Chapter 9 and 10 of the Chemical Safety Report for detailed information). Thus, long-term testing with aquatic invertebrates and fish is not deemed necessary. 2-(1-methylethoxy)ethyl acetate did not cause inhibition of biodegradation in a study according to OECD 301C with activated sludge microorganisms. No toxicity/inhibition of degradation was observed at the applied test concentration of 100 mg/L in the toxicity control, and thus a NOEC (14 d) ≥ 100 mg/L was derived. The overall potential to cause inhibition of activated sludge microorganisms is low and significant inhibition of the subsequent degradation process in sewage treatment plants is not expected.