Registration Dossier
Registration Dossier
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EC number: 455-040-5 | CAS number: 3789-59-1
Endpoint summary
Administrative data
Description of key information
skin (in vivo)
Rabbit (OECD 404): highly corrosive (Calvert Preclinical Services, Inc. 2001)
Eye (ex vivo)
(S)-1 -Phenyl-propylamine (CAS 3789-59-1) was irritating after application on rabbit eyes. [Calvert Preclinical Services, 2000]
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin
The potential of (S)-1-Phenylpropylamine (CAS 3789-59-1) to cause acute dermal irritation or corrosion was assessed in vivo in rabbits. The test substances caused full thickness necroses within an exposure time of 3 min. [Calvert Preclinical Services, 2001]
Eye
A study was performed to assess the ocular irritancy potential of (S)-1-Phenylpropylamine (CAS 3789-59-1) in the rabbit following application onto the cornea of the enucleated eye. The rabbit enucleated eye test is used, as a first stage in the assessment of ocular irritancy potential. Based on the evaluation criteria defined for this test, the test substance was considered to have the potential to cause ocular irritancy in vivo. [Calvert Preclinical Services, 2000]
Respiratory system
Currently, there is no information available.
Effects on skin irritation/corrosion: highly corrosive
Effects on eye irritation: irritating
Justification for classification or non-classification
Skin
Based on the results of the in vivo experiments, the test substance needs to be labelled as “highly corrosive to the skin” (Cat. 1A), according to the criteria defined by the EU and the GHS system.
Eye
Based on the results of the results of the eye irritation test in vitro and in view of the results of the skin irritation test, the test substance is also considered as corrosive to the eye and therefore needs to be classified and labelled according to EU and GHS criteria.
Respiratory system
No data available. The substance is corrosive.
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