Registration Dossier
Registration Dossier
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EC number: 291-169-1 | CAS number: 90342-32-8
Endpoint summary
Administrative data
Description of key information
The key information for skin and eye irritation endpoints is read across from 1-decanol (CAS 112-30-1). The key study in rabbit (Eurofins 2008; rel 1) and reliability 2 human data suggest 1-decanol not to be a skin irritant. The key study for eye irritation (Eurofins 2008; rel 1) found the test substance to be an eye irritant based on corneal opacity readings of 1, iritis readings of 2 and conjunctival redness and chemosis scores of ¿2 in all animals.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
In the absence of data on the irritation potential of decanol (branched) the key information was read across from 1 -decanol (CAS 112 -30 -1). A comparative 24 hour occluded human study by Kaestner (1977) reports only slight quickly reversible irritation in human, which is supported by a study by Robinson (1998) which shows no irritant effects in man. Kaestner's comparative study highlights the effects of 1 -decanol to be more pronounced in rabbit than man.
Effects on eye irritation: irritating
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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