Registration Dossier
Registration Dossier
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EC number: 925-045-1 | CAS number: 1184842-87-2
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study performed in accordance with OECD Guideline and compliant with GLP criteria. Minor restrictions in reporting, but otherwise considered adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1184842-87-2
- Cas Number:
- 1184842-87-2
- IUPAC Name:
- 1184842-87-2
- Details on test material:
- - Substance name: C9-Diol Na-Salz
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not required
Test solutions
- Details on test solutions:
- - Stock solution: 2000 mg/L
Test organisms
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- Municipal activated sludge from laboratory units 1 u. 3, which are fed with municipal sewage. Activated sludge concentrationis 1 g/L based on dry substance
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 3 h
Test conditions
- Nominal and measured concentrations:
- - Nominal concentrations: 0 (control) and 1000 mg/L.
- Reference substance (positive control):
- yes
- Remarks:
- 3.5-Dichlorphenol
Results and discussion
Effect concentrations
- Duration:
- 30 min
- Dose descriptor:
- EC50
- Effect conc.:
- > 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Details on results:
- An increase rather than an inhibition of respiration was observed at the test concentration of 1000 mg/L. The test substance is an aqueous solution with about 20 - 30% active incredient. Based on the active incredient and as a conservative approach, the 16h EC10 is determined at >200 mg/L.
- Results with reference substance (positive control):
- - EC20 = ca. 1.5 mg/L
- EC50 = ca. 6.5 mg/L
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
