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Long-term toxicity to fish

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Description of key information

NOEL (32d) = 63.4 mg a.i./L (Pimephales promelas)

Key value for chemical safety assessment

Additional information

No information about the chronic toxicity of sodium 2,4 -dichlorophenoxyacetate (CAS No. 2702-72-9) to fish species is available. However, since this substance is highly soluble and it is rapidly dissociated in water, being 2,4-dichlorophenoxyacetic acid (CAS No. 94-75-7) its main product, conclusions about this endpoint could be drawn based on 2,4-D acid data. Mayes et al. (1990) investigated the long-term effect of 2,4-D acid in early-life stages of Pimephales promelas for 32 days, using a flow-through water regime. This test was conducted according to EPA/FIFRA Guideline E72-4, International Standard Method for testing Acute Toxicity to Fish, under GLP conditions. A reduction on larval survival was observed between days 5 and 14 whereas no effects on hatching success, larval length or weight were reported at any concentration tested. At test termination, a NOEL of 63.4 mg a.i./L was determined.