Registration Dossier

Toxicological information

Genetic toxicity: in vitro

Currently viewing:

Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Type of information:
other: OECD Toolbox v3.4 read across study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019
Report date:
2019

Materials and methods

Test guideline
Guideline:
OECD Guideline 471 (Bacterial Reverse Mutation Assay)
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2,2,6,6-pentamethylpiperidin-4-ol
EC Number:
219-292-8
EC Name:
1,2,2,6,6-pentamethylpiperidin-4-ol
Cas Number:
2403-89-6
Molecular formula:
C10H21NO
IUPAC Name:
1,2,2,6,6-pentamethylpiperidin-4-ol

Method

Species / strain
Species / strain / cell type:
S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
Metabolic activation:
with and without
Metabolic activation system:
S9

Results and discussion

Test resultsopen allclose all
Species / strain:
S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
Metabolic activation:
with
Genotoxicity:
positive
Cytotoxicity / choice of top concentrations:
not determined
Species / strain:
other: S. typhimurium TA 1535, TA 1537, TA 98, and TA 100
Metabolic activation:
without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not determined
Remarks on result:
ambiguous mutagenic potential (based on QSAR/QSPR prediction)

Applicant's summary and conclusion