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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
other: read across from 2,2,6,6 -tetramethylpiperidin-4 -ol (the analogue substance with no methyl group on N)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
See the summary of this endpoint

Data source

Reference
Reference Type:
review article or handbook
Title:
OECD SIDS 2,2’,6,6’-TETRAMETHYLPIPERIDIN-4-OL
Author:
OECD
Year:
2002
Bibliographic source:
OECD SIDS 2,2,6,6-Tetramethylpiperidin-4-ol (CAS 2403-88-5)
Report date:
2002

Materials and methods

Test guideline
Guideline:
OECD Guideline 406 (Skin Sensitisation)
GLP compliance:
not specified
Type of study:
other: read across
Justification for non-LLNA method:
Available (older) study

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2,6,6-tetramethylpiperidin-4-ol
EC Number:
219-291-2
EC Name:
2,2,6,6-tetramethylpiperidin-4-ol
Cas Number:
2403-88-5
Molecular formula:
C9H19NO
IUPAC Name:
2,2,6,6-tetramethylpiperidin-4-ol

In vivo test system

Test animals

Species:
guinea pig

Results and discussion

In vivo (non-LLNA)

Results
Reading:
other: skin sensitisation score
Group:
test chemical
Dose level:
0
No. with + reactions:
0
Total no. in group:
0
Clinical observations:
This substance is classified as a moderate to strong sensitizer in albino guinea pigs according to the grading of Magunusson and Kligman.
Remarks on result:
positive indication of skin sensitisation

Applicant's summary and conclusion

Interpretation of results:
sensitising