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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
other: read across from 2,2,6,6 -tetramethylpiperidin-4 -ol (the analogue substance with no methyl group on N)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
See the summary of this endpoint

Data source

Reference
Reference Type:
review article or handbook
Title:
OECD SIDS 2,2’,6,6’-TETRAMETHYLPIPERIDIN-4-OL
Author:
OECD
Year:
2002
Bibliographic source:
OECD SIDS 2,2,6,6-Tetramethylpiperidin-4-ol (CAS 2403-88-5)
Report date:
2002

Materials and methods

Test guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2,6,6-tetramethylpiperidin-4-ol
EC Number:
219-291-2
EC Name:
2,2,6,6-tetramethylpiperidin-4-ol
Cas Number:
2403-88-5
Molecular formula:
C9H19NO
IUPAC Name:
2,2,6,6-tetramethylpiperidin-4-ol

Test animals

Species:
rabbit

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Score:
5.5
Max. score:
8
Reversibility:
not reversible
Remarks on result:
other: highly irritating

Applicant's summary and conclusion

Interpretation of results:
Category 1 (corrosive) based on GHS criteria

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