Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
1 285 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

With an LD 50 (oral, rat) of 1285 mg/kg this substance must be classified for Acute Toxicity Category 4 with GHS pictogram exclamation mark (GHS07), signal word Warning and H302: Harmful if swallowed.

This level of oral toxicity (rat) is supported by the LD50 (oral, rat) as mentioned in the OECD SIDS for the analogue substance 2,2’6,6’-TETRAMETHYLPIPERIDIN-4-OL (CAS 2403 -88 -5) which is missing the CH3-group on the nitrogen atom, and as measured by OECD TG401: 1482 mg/kg (male) and 1564 mg/kg (female). This OECD SIDS has been attached to the IUCLID dossier.