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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1973
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: early study report, scientifically acceptable

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Hex-3-yne-2,5-diol
EC Number:
221-209-5
EC Name:
Hex-3-yne-2,5-diol
Cas Number:
3031-66-1
Molecular formula:
C6H10O2
IUPAC Name:
hex-3-yne-2,5-diol

Test animals

Species:
rat
Strain:
other: Gassner
Sex:
male/female
Details on test animals or test system and environmental conditions:
Mean body weights for male animals 202 g, for female animals 174 g

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
The test substance was administered as a 16%, 2% or 1% aqueous solution.
Doses:
50, 100, 125, 160, 200, 1600 µL/kg bw
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
approximate LD50
Effect level:
140 other: µl/kg
Based on:
test mat.
Mortality:
50 and 100 µL/kg bw: no mortalities
125 µL/kg bw: 1/5 males and 0/5 females after 7 days
160 µL/kg bw: 5/5 males and 2/5 females after 7 days
200 µL/kg bw: 4/5 males and 5/5 females after 7 days
1600 µL/kg bw: 5/5 males and 5/5 females after 7 days
Clinical signs:
other: apathy, dyspnea
Gross pathology:
acute heart dilatation, acute congestive hyperemia; liver: loam-grey spotted with blunted margins; kidneys: brightened complexion; stomach: bloody ulcerations, ascites, slight lung edema.

Any other information on results incl. tables

µL = mg (densitiy 0.996 g/mL)

Applicant's summary and conclusion