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EC number: 205-126-1 | CAS number: 134-03-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The acute toxicity was investigated in 5 studies, 3 using rats and 2 using mice that received either a single dose or were treated on five consecutive days. No signs of toxicity were seen in any of the studies. The LD50 values were > 11,000 mg/kg bw in the rat and > 9,400 mg/kg bw in the mouse.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- equivalent or similar to OECD 401; not to present GL, minimal reporting standard, not GLP, CAS number, source, purity, known impurities, lot number are missing, strain, age and housing conditions of rats not given, not single application
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- pre-guideline study
- Principles of method if other than guideline:
- Studies were conducted before the OECD Guidelines for the Testing of Chemicals were established.
Mice and rats were used in the experiments. Animals received the test item at doses of (2.5, 5, 10, or 20 g/kg bw/d) orally by gavage once daily on five consecutive days. Bodyweight gain was measured and the animals were monitored for a total of 15 days. LD10, LD50, and LD90 values were calculated. - GLP compliance:
- no
- Test type:
- other: no data
- Specific details on test material used for the study:
- CAS number: 134-03-2
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- animals were dosed on five consecutive days.
- Doses:
- 20.000,
10.000,
5.000,
2.500 mg/kg bw - Control animals:
- not specified
- Details on study design:
- Observation period was 15 days.
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 14 100 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 13 000 - 15 200
- Remarks on result:
- other: after 15 days
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The results of the acute toxicity studies do not meet the classification criteria for acute oral toxicity as the LD50 was determined to be 14,100 mg/kg.
- Executive summary:
In rats receiving sodium ascorbate by oral gavage on five consecutive days at dose levels of 2,500, 5,000, 10,000 and 20,000 mg/kg/day, the LD50 was 14,100 mg/kg. The observation period was15 days (Hoffmann-La Roche, 1976). The result of this study repeated dose study can be used in a weight of evidence approach to assess the acute oral toxicity of the test substance.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- equivalent or similar to OECD 401; not to present GL, minimal reporting standard, not GLP, CAS number, source, purity, known impurities, lot number are missing, strain, age and housing conditions of rats not given, not single application
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- pre-guideline study
- Principles of method if other than guideline:
- Studies were conducted before the OECD Guidelines for the Testing of Chemicals were established.
Mice and rats were used in the experiments. Animals received the test item at doses of (2.5, 5, 10, or 20 g/kg bw/d) orally by gavage once daily on five consecutive days. Bodyweight gain was measured and the animals were monitored for a total of 15 days. LD10, LD50, and LD90 values were calculated. - GLP compliance:
- no
- Test type:
- other: not available
- Specific details on test material used for the study:
- CAS number: 134-03-2
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Animals were dosed on five consecutive days
- Doses:
- 20.000
10.000
5.000
2.500 mg/kg bw - Control animals:
- not specified
- Details on study design:
- Observation period was 15 days.
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 9 400 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 7 980 - <= 10 880
- Remarks on result:
- other: after 15 days
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The results of the acute toxicity studies do not meet the classification criteria for acute oral toxicity as the LD50 was determined to be 9,400 mg/kg.
- Executive summary:
In mice receiving sodium ascorbate by oral gavage on five consecutive days at dose levels of 2,500, 5,000, 10,000 and 20,000 mg/kg/day, the LD50 was 9,400 mg/kg. The observation period was15 days (Hoffmann-La Roche, 1976). The result of this repeated dose study can be used in a weight of evidence approach to assess the acute oral toxicity of the test substance.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Not to present GL, minimal reporting standard (no details, symptoms etc.), not GLP, CAS number, source, purity, known impurities are missing, strain, source, age, weight and housing conditions of rats not given, observation only 10 d
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- pre-guideline study, i.e. no guideline was available at the time of the study
- Principles of method if other than guideline:
- Studies were conducted before the OECD Guidelines for the testing of chemicals were established.
Ten mice per dose group were used. Animals received the test item at different doses orally by gavage and were monitored for ten days. LD10, LD50, and LD90 values were calculated. - GLP compliance:
- no
- Remarks:
- pre-GLP study
- Test type:
- standard acute method
- Specific details on test material used for the study:
- Identification: Sodium ascorbate crystalline
CAS number: 134-03-2
Batch Number: TL00910581
Purity: >99 %
Appearance: White to yellowish crystalline powder
Expiry Date (as given by the sponsor): April 01, 2011 - Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 16 300 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 14 700 - <= 18 800
- Remarks on result:
- other: after 10 days
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The results of the acute toxicity studies do not meet the classification criteria for acute oral toxicity.
- Executive summary:
The oral LD50 in the rat was 16,000 mg/kg in a poorly documented pre-guideline study (Hoffmann-La Roche, 1973). The result can be used in a weight of evidence approach.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Not to present GL, minimal reporting standard (no details, symptoms etc.), not GLP, CAS number, source, purity, known impurities are missing, strain, source, age, weight and housing conditions of rats not given, observation only 10 d
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- pre-guideline study, i.e. no guideline was available at the time of the study
- Principles of method if other than guideline:
- Studies were conducted before the OECD Guidelines for the Testing of Chemicals were established.
Ten mice per dose group were used. Animals received the test item at different doses orally by gavage and were monitored for ten days. LD10, LD50, and LD90 values were calculated. - GLP compliance:
- no
- Remarks:
- pre-GLP study
- Test type:
- other: not avaialble
- Specific details on test material used for the study:
- CAS number: 134-03-2
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 17 531 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 14 960 - <= 20 102
- Remarks on result:
- other: after 10 days
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The results of the acute toxicity studies do not meet the classification criteria for acute oral toxicity.
- Executive summary:
The oral LD50 in the mouse was 17,531 mg/kg in a poorly documented pre-guideline study (Hoffmann-La Roche, 1973). The result can be used in a weight of evidence approach.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: equivalent or similar to OECD 401
- Remarks:
- Not to present GL, minimal reporting standard (no details, symptoms etc.), not GLP, CAS number, source, purity, known impurities are missing, strain, source, age, weight and housing conditions of rats not given, not single application
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Studies were conducted before the OECD Guidelines for the Testing of Chemicals were established.
Mice and rats were used in the experiments. Animals received the test item at doses of (4, 8, or 16 g/kg bw/d) orally by gavage once daily on five consecutive days. Bodyweight was measured and the animals were monitored for a total of 15 days. LD10, LD50, and LD90 values were calculated. - GLP compliance:
- no
- Remarks:
- pre-guideline study
- Test type:
- standard acute method
- Specific details on test material used for the study:
- CAS Number: 134-03-2
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 11 289 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 10 390 - <= 12 188
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The results of the acute toxicity studies do not meet the classification criteria for acute oral toxicity as the LD50 was determined to be > 11,000 mg/kg.
- Executive summary:
In rats receiving sodium ascorbate by oral gavage on five consecutive days, the LD50 was > 11,000 mg/kg; the observation period was15 days (Hoffmann-La Roche, 1971). The result of this study can be used in a weight of evidence approach.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 11 000 mg/kg bw
- Quality of whole database:
- Reporting is limited but results are comparable across the studies. The results indicate in a weight of evidence approach that the substance is not acutely toxic.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
The available experimental test data is reliable and suitable for classification purposes under Regulation (EC) No 1272/2008. Based on available data on acute toxicity, the test item is not classified for acute toxicity oral, acute toxicity inhalation or acute toxicity dermal according to Regulation (EC) No 1272/2008 (CLP), as amended for the tenth time in Regulation (EU) No 2017/776.
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