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Endpoint specific guidance (ECHA, 2008) indicates that absorption of substances following exposure by inhalation, skin contact or ingestion may be predicted based on log Pow and water solubility. Experimentally determined results for substances in this category are as follows:

Substance

Log Pow

Solubility (mg/l)

Resin acids and Rosin acids, fumarated, esters with glycerol

2.44->6.5

<1.37

Rosin, fumarated, reaction products with glycerol and pentaerthythritol

4.58 (pH 4.47-5.68)

10

Resin acids and rosin acids, fumarated esters with pentaerthythritol

3.41 (Ph 6.34-6.49)

<1

Resin acids and Rosin acids, maleated, esters with pentaerythritol

4.39->6.5

>105

ECHA (2008) indicates that uptake of substances by the lung and gastrointestinal tract is favoured by moderate log P values (between -1 and 4) with micellular solubilisation favoured where log P is >4 and water solubility is low (< 1 mg/l). Data summarised above suggests that diffusion is unlikely to play a significant role in the absorption of substances included in this category, however micelle formation may facilitate uptake of Resin acids and rosin acids, fumarated, esters with glycerol in the gut. A low vapour pressure means that substances in this category are unlikely to exist as vapour, with exposure limited to inhalation of material deposited as particles.

Dermal absorption of highly water soluble substance may occur where the log Pow is between 1-4 with log Pow values between 2 and 3 favouring uptake. When log Pow exceeds 4, penetration may be limited by the rate of transfer between the stratum corneum and epidermis although uptake of a substance by the stratum corneum will be high. Uptake of substances where log Pow exceeds 6 will be low (ECHA, 2008). Based on these criteria, Rosin, fumarated, reaction products with glycerol and pentaerythritol may enter the stratum corneum however the possibility for absorption of the other category members (either by stratum corneum or skin as a whole) is not clear.

No experimental data are available to characterise the toxicokinetic behaviour of substances in this category.