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EC number: 601-145-8 | CAS number: 111974-73-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Both eyes of each rabbit were examined within the twenty-four hours prior to the study. The test substance was applied into the conjunctival sac of the left eye of the rabbit. The lids were gently held together for 1-2 sectonds after which the animal was released. The other eye was untreated (control eye). Immediately after the application of the test substance, an assessment of the initial pain reaction of the rabbit was made.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- phenyl N-[2-(phenylsulfanyl)phenyl]carbamate
- EC Number:
- 601-145-8
- Cas Number:
- 111974-73-3
- Molecular formula:
- C19H15NO2S
- IUPAC Name:
- phenyl N-[2-(phenylsulfanyl)phenyl]carbamate
- Test material form:
- solid: crystalline
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Untreated eye acts as a control
- Amount / concentration applied:
- 100 mg (approx)
- Duration of treatment / exposure:
- 4 d
- Observation period (in vivo):
- 4 d
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- Both eyes of each rabbit were examined within the twenty-four hours prior to the study. Initially, the test substance was applied into the conjunctival sac of the left eye of one rabbit. The lids were gently held together for 1-2 sectonds after which the animal was released. The other eye was untreated (control eye). Immediately after the application of the test substance, an assessment of the initial pain reaction of the rabbit was made.
After 24 h the irritation was less than severe, so the test substance was applied into the test eyes of the remaining two animals and an assessment of initial pain reaction was made. They eyes were examined and the Draize scale was used to assess the grade of ocular reaction 1-2 hours, 1, 2, and 3 days after application of the test substance. One animal was also observed 4 days after application of the test substance. In addition, as an aid in the assessment of corneal damage, fluorescein staining was used at the 1, 2, 3 and 4-day readings. A modified form of the Kay and Calandra stystem was used to interpret and classify the scores.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- other: 2 h, 1, 2, 3, 4 d
- Score:
- 0
- Max. score:
- 80
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- other: 2 h, 1, 2, 3, 4 d
- Score:
- 0
- Max. score:
- 10
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- other: 2 h
- Score:
- 9.3
- Max. score:
- 20
- Reversibility:
- fully reversible within: 2 d
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- other: 1 d
- Score:
- 3.3
- Max. score:
- 20
- Reversibility:
- fully reversible within: 2 d
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- other: 2, 3, 4 d
- Score:
- 0
- Max. score:
- 20
- Irritant / corrosive response data:
- Initial pain reaction (0-5 scale): prac. none (class 1)
Final irritation score (1-8 scale): slight irritant (class 3)
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Kay and Calandra (1962)
- Conclusions:
- Application into the rabbit eye caused practically no initial pain (class 1 on a 0-5 scale).
Conjunctival effects were seen in all three rabbits and consisted of moderate redness, slight or mild chemosis and slight or moderate discharge. There were no corneal or iridial effects. All signs of irriation had disappeared by two days. Classified as a slight irritatnt (class 3 on a 1-8 scale) to the rabbit eye.
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