Registration Dossier
Registration Dossier
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EC number: 295-714-4 | CAS number: 92128-22-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
In a guinea pig maximization test (GPMT) according to OECD TG 406 the test substance revealed a skin sensitizing potential at challenge concentrations of 0.5 and 1 %. 48 hours after the challenge skin reactions were observed in 95 % of the animals (grade 1 to 3) after 1 % test item and in 55 % of the animals (grade 1 to 2) after 0.5 % test item. 72 hours after the challenge skin reactions still persisted in most of the affected animals (Dreist and Kolb, 1993).
Migrated from Short description of key information:
The substance is sensitizing to the skin.
Justification for selection of skin sensitisation endpoint:
Only one study available
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
This information is not available.
According to REACH Annex VII-X data on respiratory sensitisation is not required for substances manufactured or imported in quantities of 1000 tonnes or more.
Justification for classification or non-classification
Skin sensitisation
Not classified under Annex I of Directive 67/548/EEC or Annex VI-1 of Regulation (EC) No 1272/2008. Differing from this a skin sensitizing potential in guinea pigs detected in a GPMT leads to the following classification according to Annex I of Regulation (EC) No 1272/2008: Category 1B (H317: May cause an allergic skin reaction).
Respiratory sensitisation
Not classified under Annex I of Directive 67/548/EEC. According to Annex I of Regulation (EC) No 1272/2008 no classification is required for respiratory sensitisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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