Registration Dossier
Registration Dossier
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EC number: 500-201-8 | CAS number: 68213-23-0 1 - 2.5 moles ethoxylated
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to Guideline study with acceptable restrictions (non-GLP).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- 24 h exposure; 48h scoring is missing.
- GLP compliance:
- no
Test material
- Reference substance name:
- Octadecan-1-ol, ethoxylated
- Cas Number:
- 9005-00-9
- Molecular formula:
- (C2H4O)nC18H38O
- IUPAC Name:
- Octadecan-1-ol, ethoxylated
- Details on test material:
- - Name of test material (as cited in study report): trade name
- Ethoxylation degree: 2
- Physical state: White solid
- Analytical purity: 100% a.i. (info by sponsor)
- Lot/batch No.: No data
- Storage condition of test material: No data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: only "albino rabbit" reported
- Details on test animals or test system and environmental conditions:
- No data.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: shaved and abraded, but only scores of shaved skin were considered.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 h
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- out of 6 animals
- Time point:
- other: mean (24,48,72 h)
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: No 48 h data are available; for calculation of mean scores, the 48 h values were assumed to be the same as those at 24 h (worst case assumption: persistence of effects seen at 24 h over 48 h).
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- out of 6 animals
- Time point:
- other: mean (24,48,72 h)
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: No 48 h data are available; for calculation of mean scores, the 48 h values were assumed to be the same as those at 24 h (worst case assumption: persistence of effects seen at 24 h over 48 h).
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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